DE NOVO Synonyms: 39 Similar and Opposite Words

de novo

adverb

di-ˈnō-(ˌ)vō

Definition of de novo

as in again

yet another time since a mistrial was declared, the case will have to be tried de novo

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Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.

Recent Examples of de novo Tucker was diagnosed in 2022, at age 28, with de novo metastatic breast cancer at Winship Cancer Institute of Emory University at Emory Saint Joseph’s Hospital. — Roni Robbins, AJC.com, 16 Oct. 2026 The vast majority of AI devices go to market through the FDA’s 510(k) clearance pathway; fewer than 10 each year receive de novo classification, which typically requires more clinical evidence. — Katie Palmer, STAT, 11 Sep. 2026 Kalver had de novo metastatic breast cancer, meaning the disease had spread beyond the breast and nearby lymph nodes to to distant areas of the body, before it was first diagnosed. — Emily Cegielski, Flow Space, 24 Aug. 2026 By contrast, government lawyers demanding payment of an FCC fine must prove to a jury in a de novo trial that the company violated the law. — ArsTechnica, 4 June 2026 The partnership, which includes licensing, co-development, and co-commercialization opportunities across a diverse portfolio of antibody-drug conjugates, will involve the research and development of 12 breakthrough early-stage and de novo cancer medicines, the company said in a filing. — Justina Lee, CNBC, 29 May 2026 In 2025, the OCC reported 14 de novo charter applications, several tied to novel and digital-asset activity. — Frank Sorrentino, Forbes.com, 23 Jan. 2026 Because this technology is new, PreEvnt is pursuing a de novo pathway, which allows devices to be evaluated while standards are still being defined. — Kurt Knutsson, FOXNews.com, 17 Jan. 2026 The agency signed off on de novo charters for Circle and Ripple, while approving conversions from state trust companies to national trust banks for BitGo, Fidelity and Paxos. — Julia Shapero, The Hill, 12 Dec. 2025

Recent Examples of Synonyms for de novo

again

Adverb

Netflix is obviously against the ropes again, after slowing user engagement on the service rattled Wall Street investors and layoffs came this week as a sacrifice to the share price.

— Matt Donnelly, Variety, 16 Oct. 2026
Here again, discrimination and exploitation of the Jews were initially justified on the basis of economic requirements.

— Arkansas Online, Arkansas Online, 16 Oct. 2026

Definition of again

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denouncing

de novo

dens

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“De novo.” Merriam-Webster.com Thesaurus, Merriam-Webster, https://www.merriam-webster.com/thesaurus/de%20novo. Accessed 21 Oct. 2026.

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Synonyms of de novo

adverb

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